Painkiller to relieve chronic diabetes pain
Last updated 19/07/2010 12:36:48
Painkiller to relieve chronic diabetes pain
Scientists could be one step closer to developing a unique painkiller for millions of people worldwide with diabetes, who currently have little in the way of effective treatments for the severe chronic pain associated with diabetes.
The Wellcome Trust has awarded £4.3 million to a team of researchers led by David Wynick, Professor of Molecular Medicine at the University of Bristol, to develop a new analgesic drug based on the protein galanin.
Galanin is a small protein made by the pain sensing cells and its levels greatly increase after injury or damage to these nerves. After 10 years investigating its function, Prof Wynick and his colleague Dr Fiona Holmes have shown that galanin reduces neuropathic pain in a number of models of disease. Research into the use of galanin for multiple sclerosis and Alzheimer's disease has also had positive initial results.
Diabetes is the commonest cause of neuropathic pain which is often experienced as a burning or electrical pain and to date existing painkillers have proved largely ineffective. Latest estimates by the World Diabetes Foundation predict that the world's population of diabetes sufferers will jump from 285 million in 2010 to 438 million by 2030 given the increasing levels of obesity, and in the UK about 5% of the population currently have diabetes.
Of those with diabetes, over half will develop peripheral nerve damage (neuropathy) and 15-20% of those patients will develop chronic neuropathic pain, indicating the potentially huge market for a more effective painkiller. It should take about three years to develop a drug suitable for testing in human trials and if those studies were successful then at least another eight years before the drug was commercially available.
Prof Wynick said: "A drug that mimics the effects of galanin could offer relief to the millions of people with diabetes worldwide that currently suffer from this debilitating pain."